A synthetic glucocorticoid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Triamcinolone

Item No. 28275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione
CAS Number
124-94-7
Synonyms
  • NSC 13397
  • TRI
Molecular Formula
C21H27FO6
Formula Weight
394.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:6): 0.14 mg/mlDMSO: 15 mg/ml
λmax
240 nm
SMILES
F[C@]12[C@@]([C@@](C[C@@H](O)[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(C=C[C@@]41C)=O
InChi Code
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChi Key
GFNANZIMVAIWHM-OBYCQNJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $32

    Add

    100 mg

    $52

    Add

    250 mg

    $98

    Add

    500 mg

    $164

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    Triamcinolone is a synthetic glucocorticoid.1,2 It increases expression of the calcitonin receptor in murine osteoclast-like cells when used at a concentration of 1 μM.3 Triamcinolone (3 mg/kg, s.c.) reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain.1 It also reduces levels of the glycosaminoglycans (GAGs) hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice.4 Triamcinolone has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.5 LNPs containing triamcinolone and encapsulating reporter mRNA reduce LNP-induced increases in the serum levels of inflammatory cytokines in mice to a greater extent than LNPs that do not contain triamcinolone. LNPs containing triamcinolone and encapsulating MOG35-55 mRNA reduce spinal cord CD3+ T cell infiltration and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hayashi, R., Xiao, W., Kawamoto, M., et al. Systemic glucocorticoid therapy reduces pain and the number of endoneurial tumor necrosis factor-alpha (TNFα)-positive mast cells in rats with a painful peripheral neuropathy. J. Pharmacol. Sci. 106(4), 599-565 (2008).

    2. Uete, T., and Ashmore, J. Effects of triamcinolone on carbohydrate synthesis by rat liver slices. The Journal of Biological Chemisty 238(9), 2906-2911 (1963).

    3. Wada, S., Udagawa, N., Akatsu, T., et al. Regulation by calcitonin and glucocorticoids of calcitonin receptor gene expression in mouse osteoclasts. Endocrinology 138(2), 521-529 (1997).

    4. Shetlar, M.R., Shetlar, D.J., Bloom, R.F., et al. Involution of keloid implants in athymic mice treated with pirfenidone or with triamcinolone. J. Lab Clin. Med. 132(6), 491-496 (1998).

    5. Thatte, A.S., Nachod, B.E., Baena, J., et al. Ionizable lipid-dependent optimization of steroid lipid nanoparticles with tunable immunomodulatory properties. Adv. Mat. e74301 (2026).