A competitive STING ligand
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STING18

Item No. 28319

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-chloro-4-(1,1-dimethylethyl)phenyl]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1,2,3,4-tetrahydro-1-oxo-4-isoquinolineacetic acid
CAS Number
2706536-26-5
Synonyms
  • Stimulator of Interferon Genes 18
Molecular Formula
C29H27ClFNO5
Formula Weight
524.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 5 mg/ml
SMILES
FC1=CC=C2C(C(N(C3=CC(Cl)=C(C(C)(C)C)C=C3)C(C4=CC(OCCO5)=C5C=C4)C2CC(O)=O)=O)=C1
InChi Code
InChI=1S/C29H27ClFNO5/c1-29(2,3)22-8-6-18(14-23(22)30)32-27(16-4-9-24-25(12-16)37-11-10-36-24)20(15-26(33)34)19-7-5-17(31)13-21(19)28(32)35/h4-9,12-14,20,27H,10-11,15H2,1-3H3,(H,33,34)
InChi Key
JAIAHSWXASHNQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 µM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 µM) but does not stimulate IFN-β production (EC50 = >30 µM) in THP-1 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019).