An analog of GSK484
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Product Type

Biochemicals

Research Area

Cancer
Cell Death

CAY10740 (hydrochloride)

Item No. 28320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((3S,4R)-3-amino-4-hydroxypiperidin-1-yl)(2-(1-benzyl-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone, monohydrochloride
Molecular Formula
C30H31N5O3 • HCl
Formula Weight
546.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 5 mg/mlEthanol: 0.3 mg/ml
λmax
244, 304 nm
SMILES
COC1=C2C(N=C(C3=CC4=C(C=CC=C4)N3CC5=CC=CC=C5)N2C)=CC(C(N6CC[C@@H](O)[C@@H](N)C6)=O)=C1.Cl
InChi Code
InChI=1S/C30H31N5O3.ClH/c1-33-28-23(14-21(16-27(28)38-2)30(37)34-13-12-26(36)22(31)18-34)32-29(33)25-15-20-10-6-7-11-24(20)35(25)17-19-8-4-3-5-9-19;/h3-11,14-16,22,26,36H,12-13,17-18,31H2,1-2H3;1H/t22-,26+;/m0./s1
InChi Key
NQSFYHJUSFDAJX-UVDUPURASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $75

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    5 mg

    $312

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    10 mg

    $544

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    Product Description

    CAY10740 is an analog of the protein arginine deiminase 4 (PAD4) inhibitor GSK484 (Item No. 17488).1 It decreases the viability of 4T1 cells by 85 and 98% when used at concentrations of 5 and 10 μM, respectively, which is more than five-fold as effective as GSK484.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, Z., Shi, L., Wang, B., et al. Synthesis of reversible PAD4 inhibitors via copper-catalyzed C−H arylation of benzimidazole. Sci. China Chem. 62(6), 592-596 (2019).