A PDE inhibitor
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Isomer(s)
42071Methylliberine
Labeled Version(s)
351337-(β-Hydroxyethyl)theophylline-d6
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7-(β-Hydroxyethyl)theophylline

Item No. 28372

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
519-37-9
Synonyms
  • Etophylline
  • Hydroxyethyltheophylline
  • NSC 113373
Molecular Formula
C9H12N4O3
Formula Weight
224.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMSO: 25mg/mLPBS (pH 7.2): 3mg/mL
λmax
274 nm
SMILES
O=C1N(C)C(C(N(CCO)C=N2)=C2N1C)=O
InChi Code
InChI=1S/C9H12N4O3/c1-11-7-6(8(15)12(2)9(11)16)13(3-4-14)5-10-7/h5,14H,3-4H2,1-2H3
InChi Key
NWPRCRWQMGIBOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 g

    $49

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    25 g

    $102

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    50 g

    $190

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    100 g

    $354

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    Product Description

    7-(β-Hydroxyethyl)theophylline is a methylxanthine phosphodiesterase (PDE) inhibitor.1 It reduces histamine, 5-hydroxytryptamine, and bradykinin-induced bronchoconstriction in an anesthetized guinea pig model of bronchial asthma.2 Formulations containing 7-(β-hydroxyethyl)theophylline in combination with theophylline have been used in the treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizon, J., Skandrani, E., and Mizon, C. Determination of the inhibitory activity of some new substituted theophyllines on the specific phosphodiesterase of cyclic nucleotides. Therapie 26(5), 911-917 (1971).

    2. Ufkes, J.G., Leeuwin, R.S., Ottenhof, M., et al. Efficacy of theophylline and its N-7-substituted derivatives in experimentally induced bronchial asthma in the guinea-pig. Arch. Int. Pharmacodyn. Ther. 253(2), 301-314 (1981).