A peripherally selective androgen receptor antagonist
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Cortexolone 17α-propionate

Item No. 28392

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-hydroxy-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione
CAS Number
19608-29-8
Synonyms
  • CB-03-01
Molecular Formula
C24H34O5
Formula Weight
402.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMSO: 10mg/mLEthanol: 20mg/mLEthanol:PBS (pH 7.2) (1:9): 0.1mg/mL
λmax
240, 295 nm
SMILES
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(OC(CC)=O)C(CO)=O)=C1
InChi Code
InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1
InChi Key
GPNHMOZDMYNCPO-PDUMRIMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $135

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    100 mg

    $369

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    Product Description

    Cortexolone 17α-propionate is a peripherally selective androgen receptor antagonist.1 Cortexolone 17α-propionate binds to the androgen receptor (AR) and inhibits AR-regulated transcription in a reporter assay.2 It also inhibits androgen-regulated lipid synthesis in primary human sebocytes. Cortexolone 17α-propionate inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells.2,3 It inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at a dose of 400 μg/animal.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Celasco, G., Moro, L., Bozzella, R., et al. Biological profile of cortexolone 17α-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung 54(12), 881-886 (2004).

    2. Rosette, C., Agan, F.J., Mazzetti, A., et al. Cortexolone 17α-propionate (clascoterone) is a novel androgen receptor antagonist that inhibits production of lipids and inflammatory cytokines from sebocytes in vitro. J. Drugs Dermatol. 18(5), 412-418 (2019).

    3. Rosette, C., Rosette, N., Mazezetti, A., et al. Cortexolone 17α-propionate (clascoterone) is an androgen receptor antagonist in dermal papilla cells in vitro. J. Drugs Dermatol. 18(2), 197-201 (2019).