A glycoside with laxative and gastroprotective activities
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Isomer(s)
24969Sennoside A
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Sennoside B

Item No. 28410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9R,9'S)-5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-[9,9'-bianthracene]-2,2'-dicarboxylic acid
CAS Number
128-57-4
Molecular Formula
C42H38O20
Formula Weight
862.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
269, 366 nm
SMILES
[H][C@@]1([C@](C2=C(C3=O)C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC=C2)(C5=C3C(O)=CC(C(O)=O)=C5)[H])C6=C(C(C7=C1C=CC=C7O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)C(O)=CC(C(O)=O)=C6
InChi Code
InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
InChi Key
IPQVTOJGNYVQEO-AIFLABODSA-N
Origin
Plant/Sennae folium
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $70

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    25 mg

    $132

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    50 mg

    $207

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    Product Description

    Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.1,2 It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2; Item No. 14010) in AGS gastric cells when used at a concentration of 100 µM.2 Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Franz, G. The senna drug and its chemistry. Pharmacology 47(Suppl 1), 2-6 (1993).

    2. Hwang, I.Y., and Jeong, C.S. Gastroprotective activities of sennoside A and sennoside B via the up-regulation of prostaglandin E2 and the inhibition of H+/K+-ATPase. Biomol. Ther. (Seoul) 23(5), 458-464 (2015).