Sennoside A

Sennoside A is a dianthrone glycoside with laxative and gastroprotective activities.^1,2 Ex vivo, sennoside A (30 mg/kg) increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle in mice.¹ Sennoside A (100 mg/kg, oral) increases the gastric emptying rate by 71.1% compared to control and increases the intestinal transport rate of a charcoal meal from 61.2 to 81.1% in mice.² It increases the concentration of prostaglandin E₂ (PGE₂; Item No. 14010) in AGS gastric cells in a dose-dependent manner in vitro. Intraduodenal administration of sennoside A (100 mg/kg) increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats. It also reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models, respectively, when administered at a dose of 100 mg/kg. Sennoside A is also a non-competitive inhibitor of bovine serum monoamine oxidase in vitro (IC₅₀ = 17 µM).³ Formulations containing sennoside A have been used to treat constipation and to aid in evacuation of the bowel prior to surgery or invasive colonic or rectal examinations.

WARNING This product is not for human or veterinary use.

1. Kobayashi, M., Yamaguchi, T., Odaka, T., et al. Regionally differential effects of sennoside A on spontaneous contractions of colon in mice. Basic Clin. Pharmacol. Toxicol. 101(2), 121-126 (2007).

2. Hwang, I.Y., and Jeong, C.S. Gastroprotective activities of sennoside A and sennoside B via the up-regulation of prostaglandin E₂ and the inhibition of H⁺/K⁺-ATPase. Biomol. Ther. (Seoul) 23(5), 458-464 (2015).

3. Hiraoka, A., Koike, S., Sakaguchi, S., et al. The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase. Chem. Pharm. Bull. (Tokyo) 37(10), 2744-2746 (1989).