A CXCR2 antagonist
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CXCR2-IN-1

Item No. 28426

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chloro-3-fluorophenyl)-N′-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-urea
CAS Number
1873376-49-8
Synonyms
  • CXCR2 Inhibitor 1
Molecular Formula
C19H20Cl2FN3O4S
Formula Weight
476.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
OC1=C(NC(NC2=CC=CC(F)=C2Cl)=O)C=CC(Cl)=C1S(C3CCN(C)CC3)(=O)=O
InChi Code
InChI=1S/C19H20Cl2FN3O4S/c1-25-9-7-11(8-10-25)30(28,29)18-12(20)5-6-15(17(18)26)24-19(27)23-14-4-2-3-13(22)16(14)21/h2-6,11,26H,7-10H2,1H3,(H2,23,24,27)
InChi Key
BJYOBCUGMDKPBM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $66

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    CXCR2-IN-1 is a chemokine (C-X-C motif) receptor 2 (CXCR2) antagonist (IC50 = 0.501 nM in a reporter assay).1 It inhibits chemotaxis of isolated human neutrophils induced by chemokine (C-X-C motif) ligand 1 (CXCL1; IC50 = 79.4 nM). In vivo, CXCR2-IN-1 (100 mg/kg) inhibits forebrain lesion formation in a mouse model of cuprizone-induced demyelination.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, H., Lu, H., Xu, Z., et al. Discovery of CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating disorders. Med. Chem. Lett. 7(4), 397-402 (2016).