An adenosine A1 and A3 receptor agonist
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N6-Ethyladenosine

Item No. 28428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-adenosine
CAS Number
14357-08-5
Synonyms
  • NSC 516603
Molecular Formula
C12H17N5O4
Formula Weight
295.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 75 mg/ml
λmax
212, 267 nm
SMILES
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NCC)N=CN=C32
InChi Code
InChI=1S/C12H17N5O4/c1-2-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20)8(19)6(3-18)21-12/h4-6,8-9,12,18-20H,2-3H2,1H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1
InChi Key
SHXVYOLWYFZWKE-WOUKDFQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $315

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    10 mg

    $589

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    Product Description

    N6-Ethyladenosine is an adenosine A1 and A3 receptor agonist.1 It binds selectively to rat adenosine A1 and human adenosine A3 receptors over rat adenosine A2A and A3 receptors (Kis = 4.9, 4.7, 8,900 and 1,050 nM, respectively, for the recombinant receptors in CHO cells). N6-Ethyladenosine completely inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human recombinant adenosine A3 receptor when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, Z.-G., Blaustein, J.B., Gross, A.S., et al. N6-Substituted adenosine derivatives: Selectivity, efficacy, and species differences at A3 adenosine receptors. Biochem. Pharmacol. 65(10), 1675-1684 (2003).