A modified nucleoside and FTO substrate
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N6,2′-O-Dimethyladenosine

Item No. 45570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-2′-O-methyl-adenosine
CAS Number
57817-83-1
Synonyms
  • m6Am
  • N6,2-O-Dimethyladenosine
Molecular Formula
C12H17N5O4
Formula Weight
295.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
CNC1=C(N=C2)C(N2[C@@H]3O[C@H](CO)[C@H]([C@H]3OC)O)=NC=N1
InChi Code
InChI=1S/C12H17N5O4/c1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20-2)8(19)6(3-18)21-12/h4-6,8-9,12,18-19H,3H2,1-2H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1
InChi Key
GRYSXUXXBDSYRT-WOUKDFQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    Product Description

    N6-2’-O-Dimethyladenosine (m6Am) is a modified nucleoside, a substrate of the demethylase fat mass and obesity-associated protein (FTO), and an mRNA cap modification that increases mRNA stability.1,2 It is present on specific transcripts, including fatty acid binding protein 2 (Fabp2) and Fabp5, in an obesity-dependent manner, where it is present on mRNA of wild-type but not ob/ob or high-fat diet-fed mice.1 Brain levels of m6Am are decreased in the cortex, subcortex, and cerebellum of adult rats exposed to alcohol during adolescence, while serum levels of m6Am are increased in patients with colorectal or gastric cancer.3,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ben-Haim, M.S., Pinto, Y., Moshitch-Moshkovitz, S., et al. Dynamic regulation of N6,2'-O-dimethyladenosine (m6Am) in obesity. Nat. Commun. 12(1), 7185 (2021).

    2. Hu, Y., Fang, Z., Mu, J., et al. Quantitative analysis of methylated adenosine modifications revealed increased levels of N6-methyladenosine (m6A) and N6,2'-O-dimethyladenosine (m6Am) in serum from colorectal cancer and gastric cancer patients. Front. Cell Dev. Biol. 9, 694673 (2021).

    3. Chen, Y.-Y., Gui, Z., Hu, D., et al. Adolescent alcohol exposure changes RNA modifications in adult brain by mass spectrometry-based comprehensive profiling analysis. Chinese Chem. Lett. 35(1), 108522 (2023).