An internal standard for the quantification of panobinostat
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Unlabeled Version(s)
13280Panobinostat
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Panobinostat-d4 (hydrochloride)

Item No. 28501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl-d4]-2-propenamide, monohydrochloride
Synonyms
  • LBH-589-d4
Molecular Formula
C21H19D4N3O2 • HCl
Formula Weight
389.9
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C(NO)/C=C/C(C([2H])=C1[2H])=C([2H])C([2H])=C1CNCCC2=C(C)NC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C21H23N3O2.ClH/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26;/h2-11,22-23,26H,12-14H2,1H3,(H,24,25);1H/b11-10+;/i6D,7D,8D,9D;
InChi Key
UPWMDRRETYJAKD-XYPHOAQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    Panobinostat-d4 (hydrochloride) is intended for use as an internal standard for the quantification of panobinostat (Item No. 13280) by GC- or LC-MS. Panobinostat is a pan-inhibitor of histone deacetylases (HDACs; Kis = 0.6-31 nM for HDAC1-11).1 It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cancer cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively), but not NCI H661 mouse NSCLC cells (IC50 = >800 nM).2 Panobinostat (20 mg/kg, i.p.) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, H., Yu, N., Chen, D., et al. Discovery of (2E)-3-{2-butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J. Med. Chem. 54(13), 4694-4720 (2011).

    2. Crisanti, M.C., Wallace, A.F., Kapoor, V., et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol. Cancer Ther. 8(8), 2221-2231 (2009).