A pan-HDAC inhibitor
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Labeled Version(s)
28501Panobinostat-d4 (hydrochloride)
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Panobinostat

Item No. 13280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
CAS Number
404950-80-7
Synonyms
  • LBH-589
Molecular Formula
C21H23N3O2
Formula Weight
349.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2)(1:3): 0.1 mg/mlDMSO: 33 mg/mlEthanol: 3.3 mg/ml
λmax
225, 283 nm
SMILES
CC1=C(CCNCC2=CC=C(/C=C/C(NO)=O)C=C2)C3=C(C=CC=C3)N1
InChi Code
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChi Key
FPOHNWQLNRZRFC-ZHACJKMWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Panobinostat is a pan-inhibitor of histone deacetylases (HDACs; Kis = 0.6-31 nM for HDAC1-11).1 It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively), but not NCI H661 mouse NSCLC cells (IC50 = >800 nM).2 Panobinostat (20 mg/kg, i.p.) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, H., Yu, N., Chen, D., et al. Discovery of (2E)-3-{2-butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J. Med. Chem. 54(13), 4694-4720 (2011).

    2. Crisanti, M.C., Wallace, A.F., Kapoor, V., et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol. Cancer Ther. 8(8), 2221-2231 (2009).