An anticancer taxane
Related Products
Isomer(s)
342967-epi-10-Deacetyltaxol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Natural Products

Research Area

Cancer
Cell Death

10-deacetyl Paclitaxel

Item No. 28503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,βS)-β-(benzoylamino)-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
CAS Number
78432-77-6
Synonyms
  • 10-DAP
  • 10-Deacetyltaxol
Molecular Formula
C45H49NO13
Formula Weight
811.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): Partially soluble
λmax
227 nm
SMILES
O=C([C@H](O)C1=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C2=CC=CC=C2)=O)C3=CC=CC=C3)=O)C[C@]([C@H]4OC(C5=CC=CC=C5)=O)(O)C1(C)C)[C@@]6(C)[C@@]4([H])[C@@]7(OC(C)=O)[C@@](OC7)([H])C[C@H]6O
InChi Code
InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1
InChi Key
TYLVGQKNNUHXIP-DIYBZAJCSA-N
Origin
Plant/Taxus chinensis (Pilger) Rehd
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $54

    Add

    10 mg

    $96

    Add

    25 mg

    $197

    Add

    50 mg

    $290

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    10-deacetyl Paclitaxel (10-DAP) is a taxane and precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) that has been found in Taxus and has anticancer activity.1,2 It is cytotoxic to KB carcinoma cells (EC50 = 0.027 μg/ml).1 10-DAP (16 mg/kg) reduces tumor growth in the PS mouse lymphocytic leukemia model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McLaughlin, J.L., Miller, R.W., Powell, R.G., et al. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: New antitumor taxanes from Taxus wallichiana. J. Nat. Prod. 44(3), 312-319 (1981).

    2. Pyo, S.H., Choi, H.J., and Han, B.H. Large-scale purification of 13-dehydroxybaccatin III and 10-deacetylpaclitaxel, semi-synthetic precursors of paclitaxel, from cell cultures of Taxus chinensis. J. Chromatogr. A. 1123(1), 15-21 (2006).