A taxane diterpenoid with α-glucosidase inhibitory and anticancer activities
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Isomer(s)
2850310-deacetyl Paclitaxel
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7-epi-10-Deacetyltaxol

Item No. 34296

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,βS)-β-(benzoylamino)-α-hydroxy-benzenepropanoic acid, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
CAS Number
78454-17-8
Synonyms
  • 10-Deacetyl-7-epitaxol
  • 10-Deacetyl-7-epi-paclitaxel
  • 10-Deacetyl-7-epipaclitaxel
  • 10-Desacetyl-7-epi-taxol
  • 10-Desacetyl-7-epipaclitaxel
  • 7-epi-10-deacetyl Paclitaxel
  • Ormosin VI
Molecular Formula
C45H49NO13
Formula Weight
811.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/ml
λmax
227 nm
SMILES
C[C@]1(C([C@@H](C2=C(C)[C@@H](OC([C@H](O)[C@H](C3=CC=CC=C3)NC(C4=CC=CC=C4)=O)=O)C[C@]5(O)C2(C)C)O)=O)[C@@]([C@@H]5OC(C6=CC=CC=C6)=O)([H])[C@@]([C@@]7([H])C[C@H]1O)(CO7)OC(C)=O
InChi Code
InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1
InChi Key
TYLVGQKNNUHXIP-DIYBZAJCSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    7-epi-10-Deacetyltaxol is a taxane diterpenoid and derivative of paclitaxel (Item No. 10461) that has been found in Taxus and has α-glucosidase inhibitory and anticancer activities.1,2 It inhibits α-glucosidase (IC50 = 48.8 µM) and is cytotoxic to HeLa cells (IC50 = 0.085 nM).1 7-epi-10-Deacetyltaxol induces apoptosis and DNA fragmentation in HepG2 hepatocellular carcinoma cells in a concentration-dependent manner.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dang, P.H., Nguyen, H.X., Duong, T.T.T., et al. α-glucosidase inhibitory and cytotoxic taxane diterpenoids from the stem bark of Taxus wallichiana. J. Nat. Prod. 80(4), 1087-1095 (2017).

    2. Subban, K., Singh, S., Subramani, R., et al. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2). BMC Complement. Altern. Med. 17(1), 504 (2017).