A nonpeptide CCK1 antagonist
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SR 27897

Item No. 28511

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
CAS Number
136381-85-6
Synonyms
  • Lintitript
Molecular Formula
C20H14ClN3O3S
Formula Weight
411.9
Purity
≥98%
Formulation (Request formulation change)
A solid
λmax
321 nm
SMILES
O=C(NC1=NC(C2=CC=CC=C2Cl)=CS1)C3=CC4=CC=CC=C4N3CC(O)=O
InChi Code
InChI=1S/C20H14ClN3O3S/c21-14-7-3-2-6-13(14)15-11-28-20(22-15)23-19(27)17-9-12-5-1-4-8-16(12)24(17)10-18(25)26/h1-9,11H,10H2,(H,25,26)(H,22,23,27)
InChi Key
ILNRQFBVVQUOLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $129

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    10 mg

    $231

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    25 mg

    $510

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    50 mg

    $953

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    Product Description

    SR 27897 is a nonpeptide cholecystokinin (CCK) receptor antagonist.1 It selectively binds to CCK1 receptors in rat pancreatic membranes (IC50 = 0.58 nM) over CCK2 receptors in guinea pig cortical membranes and gastrin receptors in guinea pig gastric gland suspensions (IC50s = 489 and 2,883 nM, respectively). SR 27897 inhibits amylase secretion induced by CCK in isolated rat pancreatic acini (pA2 = 7.50) and CCK-induced guinea pig gallbladder contractions ex vivo (pA2 = 9.57). It completely reverses CCK-induced amylase secretion in rats when administered at a dose of 1 mg/kg. SR 27897 also inhibits CCK-induced gastric and gallbladder emptying in mice (ED50s = 3 and 72 μg/kg, respectively). SR 27897 inhibits gallbladder emptying in a mouse model of egg yolk-stimulated endogenous CCK release (ED50 = 27 μg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gully, D., Fréhel, D., Marcy, C., et al. Peripheral biological activity of SR 27897: A new potent non-peptide antagonist of CCKA receptors. Eur. J. Pharmacol. 232(1), 13-19 (1993).