A heavy metal chelator
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meso-2,3-Dimercaptosuccinic Acid

Item No. 28515

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S)-rel-2,3-dimercapto-butanedioic acid
CAS Number
304-55-2
Synonyms
  • DMSA
  • Succimer
Molecular Formula
C4H6O4S2
Formula Weight
182.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:8): 0.1 mg/ml
SMILES
OC([C@@H](S)[C@@H](S)C(O)=O)=O
InChi Code
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
InChi Key
ACTRVOBWPAIOHC-XIXRPRMCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $86

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    10 g

    $120

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    Cayman Chemical
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    Product Description

    meso-2,3-Dimercaptosuccinic acid is a heavy metal chelator.1 It reverses sodium arsenite-induced inhibition of pyruvate dehydrogenase (PDH) in mouse kidney homogenates (EC50 = 0.25 mM). meso-2,3-Dimercaptosuccinic acid decreases cisplatin-induced increases in serum levels of platinum and blood urea nitrogen (BUN), as well as apoptosis in renal tubules of mice when administered at a dose of 100 µM/kg.2 meso-2,3-Dimercaptosuccinic acid (90 mg/kg) decreases elevations in the activity of catalase and glucose-6-phosphate dehydrogenase (G6PDH) in RBCs from lead-exposed rats, and decreases the levels of lead in the cerebellum, hippocampus, liver, kidney, and blood in rats when administered at a dose of 100 mg/kg.3,4 It decreases immobility time in the forced swim test in lead-exposed male, but not female, mice when administered at a dose of 50 mg/kg.5 Formulations containing meso-2,3-dimercaptosuccinic acid have been used in the treatment of heavy metal poisoning.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aposhian, H.V., Hsu, C.-A., and Hoover, T.D. DL- and meso-dimercaptosuccinic acid: in vitro and in vivo studies with sodium arsenite. Toxicol. Appl. Pharmacol. 69(2), 206-213 (1983).

    2. Yajima, Y., Kawaguchi, M., Yoshikawa, M., et al. The effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the nephrotoxicity in the mouse during repeated cisplatin (CDDP) treatments. J. Pharmacol. Sci. 134(2), 108-115 (2017).

    3. Gürer, H., Özgünes, H., Neal, R., et al. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology 128(3), 181-189 (1998).

    4. Zhang, J., Wang, X.-F., Lu, Z.-B., et al. The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Free Rad. Biol. Med. 37(7), 1037-1050 (2004).

    5. Stewart, P.W., Blaine, C., Cohen, M., et al. Acute and longer term effects of meso-2,3 dimercaptosuccinic acid (DMSA) on the behavior of lead-exposed and control mice. Physiol. Behav. 59(4-5), 849-855 (1996).