An internal standard for the quantification of lisinopril
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Unlabeled Version(s)
16833Lisinopril
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Lisinopril-d5

Item No. 28520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((S)-1-carboxy-3-(phenyl-d5)propyl)-L-lysyl-L-proline
CAS Number
1356905-39-9
Molecular Formula
C21H26D5N3O5
Formula Weight
410.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: solubleWater: soluble
SMILES
O=C(N1[C@H](C(O)=O)CCC1)[C@H](CCCCN)N[C@H](C(O)=O)CCC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]
InChi Code
InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17?,18?/m0/s1/i1D,2D,3D,7D,8D
InChi Key
RLAWWYSOJDYHDC-HRUOIHOHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $329

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    Product Description

    Lisinopril-d5 is intended for use as an internal standard for the quantification of lisinopril (Item No. 16833) by GC- or LC-MS. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM).1 It reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells.2 Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 µg/kg in rat and dog, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288(5788), 280-283 (1980).

    2. Desideri, G., Grassi, D., Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators Inflamm. 305087 (2008).