An internal standard for the quantification of tyramine
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Tyramine-d4 (hydrochloride)

Item No. 28531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-aminoethyl-1,1,2,2-d4)-phenol, monohydrochloride
CAS Number
1189884-47-6
Synonyms
  • 2-(4-Hydroxyphenyl)ethylamine-d4
  • p-Tyramine-d4
  • Uteramine-d4
Molecular Formula
C8H7D4NO • HCl
Formula Weight
177.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly solubleWater: slightly soluble
SMILES
OC1=CC=C(C([2H])([2H])C([2H])([2H])N)C=C1.Cl
InChi Code
InChI=1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H/i5D2,6D2;
InChi Key
RNISDHSYKZAWOK-NXMSQKFDSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $796

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    Product Description

    Tyramine-d4 is intended for use as an internal standard for the quantification of tyramine (Item No. 18601) by GC- or LC-MS. Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.1,2,3 It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively).1 Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reese, E.A., Bunzow, J.R., Arttamangkul, S., et al. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J. Pharmacol. Exp. Ther. 321(1), 178-186 (2007).

    2. Zucchi, R., Chiellini, G., Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149(8), 967-978 (2006).

    3. Maguire, J.J., Parker, W.A.E., Foord, S.M., et al. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev. 61(1), (2009).

    4. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).