An internal standard for the quantification of florfenicol
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Florfenicol-d3

Item No. 28538

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methyl-d3-sulfonyl)phenyl]ethyl]-acetamide
CAS Number
2213400-85-0
Molecular Formula
C12H11Cl2D3FNO4S
Formula Weight
361.2
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: slightly solubleMethanol: slightly soluble
SMILES
O=S(C1=CC=C([C@@H](O)[C@H](NC(C(Cl)Cl)=O)CF)C=C1)(C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1/i1D3
InChi Key
AYIRNRDRBQJXIF-BFHKXKNSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $382

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    Product Description

    Florfenicol-d3 is intended for use as an internal standard for the quantification of florfenicol (Item No. 19458) by GC- or LC-MS. Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol (Item No. 21357).1 It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC50s = 6.3-12.5 µg/ml).2 Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC50s = 0.25-4 µg/ml).3 It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM.1 Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cannon, M., Harford, S., and Davies, J. A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives. J. Antimicrob. Chemother. 26(3), 307-317 (1990).

    2. Neu, H.C., and Fu, K.P. In vitro activity of chloramphenicol and thiamphenicol analogs. Antimicrob. Agents Chemother. 18(2), 311-316 (1980).

    3. Priebe, S., and Schwarz, S. In vitro activities of florfenicol against bovine and porcine respiratory tract pathogens. Antimicrob. Agents Chemother. 47(8), 2703-2705 (2003).