An inhibitor of DNA-PK
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AZD 7648

Item No. 28598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS Number
2230820-11-6
Molecular Formula
C18H20N8O2
Formula Weight
380.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
211, 263, 319 nm
SMILES
CN1C2=CN=C(NC3=CN4C(C=C3C)=NC=N4)N=C2N(C5CCOCC5)C1=O
InChi Code
InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
InChi Key
XISVSTPEXYIKJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $332

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    25 mg

    $775

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    Product Description

    AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 0.63 nM in an enzyme assay).1 It is selective for DNA-PK over TTK (IC50 = 5.012 μM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 μM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model when administered at doses of 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib (Item No. 10621).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Finlay, M., and Verschoyle, R. Amino-triazolopyridine compounds and their use in treating cancer. (2018).