A short-chain acyl CoA
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Crotonyl-Coenzyme A (lithium salt hydrate)

Item No. 28606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(((((((R)-4-((3-((2-(((E)-but-2-enoyl)thio)ethyl)amino)-3-oxopropyl)amino)-3-hydroxy-2,2-dimethyl-4-oxobutoxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-4-hydroxytetrahydrofuran-3-yl phosphate, lithium salt hydrate
Synonyms
  • Crotonyl-CoA
Molecular Formula
C25H36N7O17P3S • 4Li [3H2O]
Formula Weight
913.4
Purity
≥90%
Formulation (Request formulation change)
A solid
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(/C=C/C)=O)=O)=O)([O-])=O)([O-])=O)[C@H]1OP([O-])([O-])=O.[Li+].[Li+].[Li+].[Li+].O.O.O
InChi Code
InChI=1S/C25H40N7O17P3S.4Li.3H2O/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32;;;;;;;/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40);;;;;3*1H2/q;4*+1;;;/p-4/b5-4+;;;;;;;/t14-,18-,19-,20+,24-;;;;;;;/m1......./s1
InChi Key
WDDOENQKNDYVKH-LCJDWNHTSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $205

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    Product Description

    Crotonyl-coenzyme A (crotonyl-CoA) is a derivative of CoA (Item Nos. 21499 | 21722) that contains the short-chain fatty acid crotonic acid (Item No. 43903).1 It is formed from lysine and tryptophan catabolism and fatty acid β-oxidation and serves as a precursor to acetyl-CoA. Crotonyl-CoA is a cofactor for crotonyl transferases, which mediate the post-translational modification of lysine residues on various proteins, including histones.2 Histone crotonylation is associated with activation of gene expression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Chen, H.-Z., and Tang, X. Crotonyl-coenzyme A (crotonyl-CoA). Trends in Endocrinol. Metab. 36(12), 1154-1155 (2025).

    2. Westerveld, M., Besermenji, K., Aidukas, D., et al. Cracking lysine crotonylation (Kcr): Enlightening a promising post-translational modification. Chembiochem 26, e202400639 (2025).