An internal standard for the quantification of nilutamide
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Unlabeled Version(s)
23953Nilutamide
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Nilutamide-d6

Item No. 28694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5-bis(methyl-d3)-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
CAS Number
1189477-66-4
Molecular Formula
C12H4D6F3N3O4
Formula Weight
323.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1N(C2=CC(C(F)(F)F)=C([N+]([O-])=O)C=C2)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])N1)=O
InChi Code
InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)/i1D3,2D3
InChi Key
XWXYUMMDTVBTOU-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $369

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    Product Description

    Nilutamide-d6 is intended for use as an internal standard for the quantification of nilutamide (Item No. 23953) by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.1 It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.2 It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.3 Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Signh, S.M., Gauthier, S., and Labrie, F. Androgen receptor antagonists (antiandrogens): Structure-activity relationships. Curr. Med. Chem. 7(2), 211-247 (2000).

    2. Simard, J., Singh, S.M., and Labrie, F. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology 49(4), 580-586 (1997).

    3. Wakeling, A.E., Furr, B.J.A., Glen, A.T., et al. Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens. J. Steroid Biochem. 15, 355-359 (1981).