A TLR8 antagonist
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CU-CPT9a

Item No. 28722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(7-methoxy-4-quinolinyl)-2-methyl-phenol
CAS Number
2165340-32-7
Molecular Formula
C17H15NO2
Formula Weight
265.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
238, 316 nm
SMILES
COC1=CC2=C(C=C1)C(C3=CC=C(O)C(C)=C3)=CC=N2
InChi Code
InChI=1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3
InChi Key
HNYBTVKYLVLWCB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8).1 It inhibits activation of NF-κB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK4, and TRAF3 protein levels in HEK-Blue cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Hu, Z., Tanji, H., et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat. Chem. Biol. 14(1), 58-64 (2018).