A TLR8 antagonist
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CU-CPT9b

Item No. 28723

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-hydroxy-3-methylphenyl)-7-quinolinol
CAS Number
2162962-69-6
Molecular Formula
C16H13NO2
Formula Weight
251.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
238 nm
SMILES
OC1=CC2=C(C=C1)C(C3=CC=C(O)C(C)=C3)=CC=N2
InChi Code
InChI=1S/C16H13NO2/c1-10-8-11(2-5-16(10)19)13-6-7-17-15-9-12(18)3-4-14(13)15/h2-9,18-19H,1H3
InChi Key
QXFYDRYRLOHSBD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).1 It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Hu, Z., Tanji, H., et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat. Chem. Biol. 14(1), 58-64 (2018).