A radical SAM enzyme substrate
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SAHO

Item No. 28725

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-[[(3S )-3-amino-3-carboxypropyl]sulfinyl]-5′-deoxy-adenosine
CAS Number
29907-86-6
Molecular Formula
C14H20N6O6S
Formula Weight
400.4
Purity
≥90% (mixture of isomers)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
O[C@H]1[C@@H](O)[C@@](N2C=NC3=C(N)N=CN=C32)([H])O[C@@H]1CS(CC[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C14H20N6O6S/c15-6(14(23)24)1-2-27(25)3-7-9(21)10(22)13(26-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+,27?/m0/s1
InChi Key
UCALNDAYBFUTCI-AVGQJNJTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $186

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    Product Description

    SAHO is a sulfoxide form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM; Item No. 13956) and a substrate for radical SAM enzymes.1 It is reductively cleaved to S-adenosylhomocysteine (SAH; Item No. 13603), 5'-deoxyadenosine (Item No. 29619), and 5'-thioadenosine sulfenic acid by the radical SAM enzymes NosL or NosN.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandalapu, D., Ji, X., and Zhang, Q. Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymes. Biochemistry 58(1), 36-39 (2019).