A 5-LO inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Atreleuton

Item No. 28736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-urea
CAS Number
154355-76-7
Synonyms
  • A-85761.0
  • ABT-761
  • VIA-2291
Molecular Formula
C16H15FN2O2S
Formula Weight
318.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
FC1=CC=C(CC2=CC=C(C#C[C@H](N(C(N)=O)O)C)S2)C=C1
InChi Code
InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
InChi Key
MMSNEKOTSJRTRI-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $148

    Add

    10 mg

    $278

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Atreleuton is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 23 nM in rat basophil leukemia cell lysates).1 It inhibits leukotriene B4 (LTB4; Item No. 20110) formation induced by A23187 (Item Nos. 11016 | 22030) in isolated human whole blood (IC50 = 160 nM). Atreleuton inhibits LTE4 and LTB4 biosynthesis in the peritoneal cavity in a rat model of anaphylaxis (ED50s = 1.4 and 0.6 mg/kg, respectively) and bronchoconstriction induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in anesthetized guinea pigs (ED50 = 3 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brooks, C.D., Stewart, A.O., Basha, A., et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J. Med. Chem. 38(24), 4768-4778 (1995).

    2. Bell, R.L., Harris, R.R., Malo, P.E., et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J. Pharmacol. Exp. Ther. 280(3), 1366-1373 (1997).