A fungal metabolite with diverse biological activities
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N,O-Diacetyltyramine

Item No. 28738

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-(acetyloxy)phenyl]ethyl]-acetamide
CAS Number
14383-56-3
Synonyms
  • 4-(2-acetamidoethyl) Phenyl Acetate
Molecular Formula
C12H15NO3
Formula Weight
221.3
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CC(OC1=CC=C(CCNC(C)=O)C=C1)=O
InChi Code
InChI=1S/C12H15NO3/c1-9(14)13-8-7-11-3-5-12(6-4-11)16-10(2)15/h3-6H,7-8H2,1-2H3,(H,13,14)
InChi Key
RNDRBPVTMKQIBA-UHFFFAOYSA-N
Origin
Bacterium/Actinoplanes sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $165

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    Product Description

    N,O-Diacetyltyramine is a fungal metabolite that has been found in P. endophytica and has diverse biological activities.1 It is active against a panel of 13 bacteria (MICs = 8-128 µg/ml), as well as a panel of nine fungi (MICs = 64-256 µg/ml). N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7, and OAW42 cancer cells when used at concentrations ranging from 10 to 5,000 nM. It is larvicidal against A. aegypti, A. albimanus, and C. quinquefasciatus mosquitos (LC50s = 724.8, 403.1, and 506.7 ppm, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mangamuri, U.K., Vijayalakshimi, M., Poda, S., et al. Bioactive metabolites produced by pseudonocardia endophytica VUK-10 from mangrove sediments: Isolation, chemical structure determination and bioactivity. J. Microbiol. Biotechnol. 25(5), 629-636 (2015).

    2. Quevedo, R., Nunez-Dallos, N., and Quinones, M.L. Larvicidal activity of single and macrocyclic tyrosine derivatives against three important vector mosquitoes. Res. Chem. Intermed. 41(8), 5283–5292 (2014).