A P-glycoprotein inhibitor
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ONT-093

Item No. 28758

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[4-[(1E)-3-ethoxy-1-propen-1-yl]phenyl]-4-[4-[(1-methylethyl)amino]phenyl]-1H-imidazol-5-yl]-N-(1-methylethyl)-benzenamine
CAS Number
216227-54-2
Synonyms
  • OC 144093
Molecular Formula
C32H38N4O
Formula Weight
494.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
274, 359 nm
SMILES
CCOC/C=C/C1=CC=C(C2=NC(C3=CC=C(NC(C)C)C=C3)=C(C4=CC=C(NC(C)C)C=C4)N2)C=C1
InChi Code
InChI=1S/C32H38N4O/c1-6-37-21-7-8-24-9-11-27(12-10-24)32-35-30(25-13-17-28(18-14-25)33-22(2)3)31(36-32)26-15-19-29(20-16-26)34-23(4)5/h7-20,22-23,33-34H,6,21H2,1-5H3,(H,35,36)/b8-7+
InChi Key
RSJCLODJSVZNQA-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $753

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    Product Description

    ONT-093 is an orally bioavailable substituted diarylimidazole inhibitor of P-glycoprotein ATPase activity (IC50 = 0.16 µM).1 It reverses drug resistance to doxorubicin (Item No. 15007), vinblastine (Item No. 11762), and paclitaxel (Item No. 10461) in human lymphoma, breast, ovarian, uterine, and colorectal cancer cell lines in vitro (EC50s = 9-38 nM). It is not cytotoxic to 15 normal, non-transformed, or tumor cell lines when used at concentrations up to 100 µM and exhibits weak cytostatic activity (average IC50 = >60 µM). ONT-093 (30 mg/kg) reverses paclitaxel drug resistance in an HCT15 human colon carcinoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Newman, M.J., Rodarte, J.C., Benbatoul, K.D., et al. Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Res. 60(11), 2964-2972 (2000).