A p75NTR ligand
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Ro 08-2750

Item No. 28772

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde
CAS Number
37854-59-4
Molecular Formula
C13H10N4O3
Formula Weight
270.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
248, 288, 335, 460 nm
SMILES
CC1=C(C=O)C=C2C(N=C(C(N3)=O)C(N2C)=NC3=O)=C1
InChi Code
InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20)
InChi Key
JDEMVNYMYPJJIM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    Cayman Chemical
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    Product Description

    Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTR in PC12 cells when used at a concentration of 100 μM.1 It also binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTR or tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niederhauser, O., Mangold, M., Schubenel, R., et al. NGF ligand alters NGF signaling via p75NTR and trkA. J. Neurosci. Res. 61(3), 263-272 (2000).

    2. Li, B., Cai, S., Zhao, Y., et al. Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway. Oncotarget 7(49), 81026-81048 (2016).