An antagonist of NPY receptor Y5
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CGP 71683 (hydrochloride)

Item No. 28778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide, monohydrochloride
CAS Number
192322-50-2
Synonyms
  • CGP 71683A
Molecular Formula
C26H29N5O2S • HCl
Formula Weight
512.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 20 mg/ml
λmax
272 nm
SMILES
NC1=NC(NC[C@@H]2CC[C@@H](CNS(C3=CC=CC4=C3C=CC=C4)(=O)=O)CC2)=NC5=C1C=CC=C5.Cl
InChi Code
InChI=1S/C26H29N5O2S.ClH/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24;/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31);1H/t18-,19-;
InChi Key
DIQDKUNCSVFGHH-VPLSKCCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $268

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    Cayman Chemical
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    Product Description

    CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay).1 It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM.2 CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Criscione, L., Rogollier, P., Batszl-Hartmann, C., et al. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest. 102(12), 2136-2145 (1998).

    2. Sheriff, S., Ali, M., Yahya, A., et al. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. Mol. Cancer Res. 8(4), 604-614 (2010).