An allosteric mGluR7 agonist
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AMN082

Item No. 28779

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride
CAS Number
97075-46-2
Molecular Formula
C28H28N2 • 2HCl
Formula Weight
465.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
C(C1=CC=CC=C1)(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChi Key
YRQCDCNQANSUPB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $141

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    25 mg

    $313

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    Product Description

    AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).1 It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR).2 It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM.3 AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson's disease induced by 6-hydroxy dopamine (6-OHDA; Item No. 25330).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mitsukawa, K., Yamamoto, R., Ofner, S., et al. A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc. Natl. Acad. Sci. USA 102(51), 18712-18717 (2005).

    2. Sukoff Rizzo, S.J., Leonard, S.K., Gilbert, A., et al. The metabotropic glutamate receptor 7 allosteric modulator AMN082: A monoaminergic agent in disguise? J. Pharmacol. Exp. Ther. 338(1), 345-352 (2011).

    3. Tian, Y., Liu, Y., Chen, X., et al. AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways. Neurochem. Int. 57(1), 8-15 (2010).

    4. Greco, B., Lopez, S., van der Putten, H., et al. Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson’s disease. J. Pharmacol. Exp. Ther. 332(3), 1064-1071 (2010).