An internal standard for the quantification of hesperetin
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Unlabeled Version(s)
10006084Hesperetin
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Hesperetin-13C-d3

Item No. 28806

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-(4-methoxy-13C-d3)phenyl)-4H-1-benzopyran-4-one
CAS Number
2750534-85-9
Molecular Formula
C15[13C]H11D3O6
Formula Weight
306.3
Purity
≥99% deuterated forms (d1-d3).
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): solubleDMF: solubleDMSO: soluble
SMILES
OC1=C(O[13C]([2H])([2H])[2H])C=CC(C2CC(C3=C(O)C=C(O)C=C3O2)=O)=C1
InChi Code
InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/i1+1D3
InChi Key
AIONOLUJZLIMTK-KQORAOOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Hesperetin-13C-d3 is intended for use as an internal standard for the quantification of hesperetin (Item No. 10006084) by GC- or LC-MS. Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.1,2,3,4,5 It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 µM.1 Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml).2 It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells.3 Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice.2 It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis.4 Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilcox, L.J., Borradaile, N.M., de Dreu, L.E., et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J. Lipid Res. 42(5), 725-734 (2001).

    2. Lee, N.K., Choi, S.H., Park, S.H., et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71(4), 174-180 (2004).

    3. Jo, S.H., Kim, M.E., Cho, J.H., et al. Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways. Arch. Pharm. Res. 42(8), 695-703 (2019).

    4. He, W., Liu, M., Li, Y., et al. Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity. Eur. J. Pharmacol. 857, 172456 (2019).

    5. Muhammad, T., Ikram, M., Ullah, R., et al. Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling. Nutrients 11(3), 648 (2019).