A non-selective JNK inhibitor
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JNK Inhibitor VII

Item No. 28831

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide
CAS Number
1408064-71-0
Synonyms
  • JNK-IN-7
  • c-Jun N-terminal Kinase Inhibitor VII
Molecular Formula
C28H27N7O2
Formula Weight
493.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: Partially soluble
λmax
284, 299 nm
SMILES
CN(C)C/C=C/C(NC1=CC=CC(C(NC2=CC=C(NC3=NC=CC(C4=CC=CN=C4)=N3)C=C2)=O)=C1)=O
InChi Code
InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+
InChi Key
RADRIIWGHYFWPP-WEVVVXLNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively).1 It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, T., Inesta-Vaquero, F., Niepel, M., et al. Discovery of potent and selective covalent inhibitors of JNK. Chem. Biol. 19(1), 140-154 (2012).