An NSAID
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Active Metabolite(s)
381164-Biphenylacetic Acid
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Fenbufen

Item No. 28851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γ-oxo-[1,1′-biphenyl]-4-butanoic acid
CAS Number
36330-85-5
Synonyms
  • CL 82204
Molecular Formula
C16H14O3
Formula Weight
254.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:20): 50µg/mlEthanol: 200 µg/ml
λmax
282 nm
SMILES
O=C(CCC(O)=O)C(C=C1)=CC=C1C2=CC=CC=C2
InChi Code
InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)
InChi Key
ZPAKPRAICRBAOD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $36

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    5 g

    $103

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    10 g

    $186

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    25 g

    $420

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    Product Description

    Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.1 Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.2 In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.1 It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).2 Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kerwar, S.S. Pharmacologic properties of fenbufen. Am. J. Med. 75(4B), 62-69 (1983).

    2. Brodgen, R.N., Heel, R.C., Speight, T.M., et al. Fenbufen: A review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain. Drugs 21(1), 1-22 (1981).