A formamidine acaricide
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Amitraz

Item No. 28852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N′-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methyl-methanimidamide
CAS Number
33089-61-1
Synonyms
  • NSC 324552
Molecular Formula
C19H23N3
Formula Weight
293.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
λmax
290 nm
SMILES
CC1=CC=C(/N=C/N(C)/C=N/C2=CC=C(C)C=C2C)C(C)=C1
InChi Code
InChI=1S/C19H23N3/c1-14-6-8-18(16(3)10-14)20-12-22(5)13-21-19-9-7-15(2)11-17(19)4/h6-13H,1-5H3/b20-12+,21-13+
InChi Key
QXAITBQSYVNQDR-ZIOPAAQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $32

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    Cayman Chemical
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    Product Description

    Amitraz is a formamidine acaricide.1 It induces mortality and reduces fecundity in adult R. annulatus when used at a concentration of 300 ppm. It is lethal to adult H. bipinosa (LC50 = 181 ppm). Amitraz (100 µM) reduces viability of primary rat hippocampal cells.2 In vivo, amitraz (170 mg/kg) increases malondialdehyde (MDA) and nitric oxide (NO) levels and decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat liver, kidney, brain, spleen, and testis.3 Dietary administration of amitraz reduces larval weight and larval and pupal survival in honey bee (A. mellifera) populations.4 Formulations containing amitraz have been used as insecticides in residential, agricultural, and veterinary settings.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ravindran, R., Jyothimol, G., Amithamol, K.K., et al. In vitro efficacy of amitraz, coumaphos, deltamethrin and lindane against engorged female Rhipicephalus (Boophilus) annulatus and Haemaphysalis bispinosa ticks. Exp. Appl. Acarol. 75(2), 241-253 (2018).

    2. Del Pino, J., Frejo, M.T., Baselga, M.J.A., et al. Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells. Neurotoxicol. Teratol. 50, 82-87 (2015).

    3. Kanbur, M., Siliğ, Y., Eraslan, G., et al. The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats. Environ. Sci. Pollut. Res. Int. 23(6), 5232-5242 (2016).

    4. Dai, P., Jack, C.J., Mortensen, A.N., et al. Chronic toxicity of amitraz, coumaphos and fuvalinate to Apis mellifera L. larvae reared in vitro. Sci. Rep. 8(1), 5635 (2018).