A TGF-β signaling activator
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SRI-011381

Item No. 28914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N′-cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea
CAS Number
1629138-41-5
Molecular Formula
C20H31N3O
Formula Weight
329.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.1 mg/ml
SMILES
O=C(NC1CCCCC1)N(CC2CCNCC2)CC3=CC=CC=C3
InChi Code
InChI=1S/C20H31N3O/c24-20(22-19-9-5-2-6-10-19)23(15-17-7-3-1-4-8-17)16-18-11-13-21-14-12-18/h1,3-4,7-8,18-19,21H,2,5-6,9-16H2,(H,22,24)
InChi Key
LNOPAJNGRAPFKZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $120

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    5 mg

    $427

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    10 mg

    $786

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    Product Description

    SRI-011381 is an activator of TGF-β signaling.1 It reduces increases in cell death and the number of dystrophic neurites induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary mouse embryonic forebrain neurons when used at a concentration of 3 µM. SRI-011381 (2 and 5 µM) increases phagocytosis of Aβ42 by greater than 20% in J774A.1 and THP-1 macrophages. It increases contextual fear conditioning freezing time and spontaneous alternations in the Y-maze, indicating prevention of memory deficits, in the APP751Lon,Swe transgenic mouse model of Alzheimer’s disease when administered at a dose of 10 mg/kg for 10 weeks.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tanga, M.J. Benzyl urea derivatives for activating TGF-β signaling. (2016).