A diterpene with diverse biological activities
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Isomer(s)
39136Palustric Acid
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Kaurenoic Acid

Item No. 28957

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-kaur-16-en-18-oic acid
CAS Number
6730-83-2
Molecular Formula
C20H30O2
Formula Weight
302.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 10 mg/ml
SMILES
C[C@]12[C@@](CC[C@]3(C4)[C@@]2([H])CC[C@@H](C4=C)C3)([H])[C@@](C(O)=O)(C)CCC1
InChi Code
InChI=1S/C20H30O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h14-16H,1,4-12H2,2-3H3,(H,21,22)/t14-,15+,16+,18-,19-,20-/m1/s1
InChi Key
NIKHGUQULKYIGE-OTCXFQBHSA-N
Origin
Plant/Acanthopanax gracilistylus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $90

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    10 mg

    $157

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    25 mg

    $341

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    Product Description

    Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.1,2,3 It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml.2 Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml).3 Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Paiva, L.A.F., Gurgel, L.A., Silva, R.M., et al. Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffi on acetic acid-induced colitis in rats. Vascul. Pharmacol. 39(6), 303-307 (2003).

    2. Henry, G.E., Adams, L.S., Rosales, J.C., et al. Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro. Cancer Lett. 244(2), 190-194 (2006).

    3. Soares, A.C.F., Matos, P.M., Dias, H.J., et al. Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: Considerations on structure-activity subject. Can. J. Chem. 97(7), 568-575 (2019).