A diterpenoid with diverse biological activities
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Palustric Acid

Item No. 39136

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,4aS,10aR)-1,2,3,4,4a,5,6,9,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid
CAS Number
1945-53-5
Synonyms
  • NSC 148945
Molecular Formula
C20H30O2
Formula Weight
302.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
[H][C@@]1([C@](C)(C(O)=O)CCC[C@]21C)CCC3=C2CCC(C(C)C)=C3
InChi Code
InChI=1S/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h12-13,17H,5-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1
InChi Key
MLBYBBUZURKHAW-MISYRCLQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Palustric acid is a diterpenoid that has been found in P. resinosa and has diverse biological activities.1,2,3,4 It increases secreted hydrogen peroxide levels in isolated mouse macrophages when used at a concentration of 2 mg/ml.1 Palustric acid is toxic to water fleas (D. magna) and rainbow trout (S. gairdneri; LC50s = 0.1 and 0.5 mg/L, respectively).2 Phloem levels of palustric acid are increased in mechanically injured, as well as mechanically injured and L. abietinum-infected, red pine and white spruce trees.3 It has been found as an environmental contaminant in pulp and paper mill effluent.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moreira, R.R., Carlos, I.Z., and Vilega, W. Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products. Biol. Pharm. Bull. 24(2), 201-204 (2001).

    2. Peng, G., and Roberts, J.C. Solubility and toxicity of resin acids. Water Res. 34(10), 2779-2785 (2000).

    3. Mason, C.J., Klepzig, K.D., Kopper, B.J., et al. Contrasting patterns of diterpene acid induction by red pine and white spruce to simulated bark beetle attack, and interspecific differences in sensitivity among fungal associates. J. Chem. Ecol. 41(6), 524-532 (2015).

    4. van den Heuvel, M.R., Ellis, R.J., Tremblay, L.A., et al. Exposure of reproductively maturing rainbow trout to a New Zealand pulp and paper mill effluent. Ecotoxicol. Environ. Saf. 51(1), 65-75 (2002).