A flavone decomposition product with diverse biological activities
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Isomer(s)
19286Esculetin
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5,7-Dihydroxychromone

Item No. 29006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-4H-1-benzopyran-4-one
CAS Number
31721-94-5
Molecular Formula
C9H6O4
Formula Weight
178.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
λmax
251, 258, 296 nm
SMILES
OC1=C(C(C=CO2)=O)C2=CC(O)=C1
InChi Code
InChI=1S/C9H6O4/c10-5-3-7(12)9-6(11)1-2-13-8(9)4-5/h1-4,10,12H
InChi Key
NYCXYKOXLNBYID-UHFFFAOYSA-N
Origin
Plant/Garcinia mangostana L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $44

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    5 mg

    $176

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    10 mg

    $263

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    25 mg

    $383

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    Product Description

    5,7-Dihydroxychromone is a flavone decomposition product that has been found in peanuts and has antioxidant activities.1 It inhibits increases in apoptosis and reactive oxygen species (ROS) induced by 6-OHDA (Item No. 25330) in SH-SY5Y neuroblastoma cells when used at concentrations of 0.4, 2, and 10 µM. 5,7-Dihydroxychromone (0.08-10 µM) increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, D.-W., Lee, K.-t., Kwon, J., et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 130, 25-30 (2015).