A fluorescent dye
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Isomer(s)
345985-Carboxytetramethylrhodamine
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6-Carboxytetramethylrhodamine

Item No. 29046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-(2,5-dicarboxyphenyl)-3,6-bis(dimethylamino)-xanthylium, inner salt
CAS Number
91809-67-5
Synonyms
  • 6-TAMRA
Molecular Formula
C25H22N2O5
Formula Weight
430.5
Purity
≥95%
Emission
572 nm
Excitation
543 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMF:PBS (pH 7.2) (1:5): 0.16mg/mLDMSO: 1mg/mL
λmax
253, 353, 546 nm
SMILES
[O-]C(C(C=CC(C(O)=O)=C1)=C1C2=C3C=CC(N(C)C)=CC3=[O+]C4=C2C=CC(N(C)C)=C4)=O
InChi Code
InChI=1S/C25H22N2O5/c1-26(2)15-6-9-18-21(12-15)32-22-13-16(27(3)4)7-10-19(22)23(18)20-11-14(24(28)29)5-8-17(20)25(30)31/h5-13H,1-4H3,(H-,28,29,30,31)
InChi Key
COCMHKNAGZHBDZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    50 mg

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    Product Description

    6-Carboxytetramethylrhodamine is a fluorescent dye that has commonly been used for the covalent labeling of oligonucleotides for DNA analysis.1,2 It displays excitation/emission maxima of 543/572 nm, respectively. 6-Carboxytetramethylrhodamine has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kvach, M.V., Stepanova, I.A., Prokhorenko, I.A., et al. Practical synthesis of isomerically pure 5- and 6-carboxytetramethylrhodamines, useful dyes for DNA probes. Bioconjug. Chem. 20(8), 1673-1682 (2009).

    2. Han, C., Chen, T., and Zu, L. Terbium chelate as donor label in time-resolved fluorescence energy transfer study of DNA hybridization. Chem. Phys. Lett. 500(4-6), 323-326 (2010).