A SIRT6 inhibitor
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OSS-128167

Item No. 29052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid
CAS Number
887686-02-4
Molecular Formula
C19H14N2O6
Formula Weight
366.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
216, 238, 279 nm
SMILES
OC(C1=CC(NC(C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=O)=CC=C1O)=O
InChi Code
InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
InChi Key
HTJWLEGCECXGSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    OSS-128167 is an inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM).1 It is selective for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167 increases acetylation of histone H3 lysine 9 (H3K9) and glucose uptake and decreases TNF-α release in BxPC-3 cells. In vivo, OSS-128167 (100 μg/animal, i.c.v.) prevents decreases in left hemisphere cerebral levels of IL-1β, TNF-α, and IL-6 and neutrophil infiltration induced by bexarotene (Item No. 11571) in a rat model of subarachnoid hemorrhage.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Damonte, P., Sociali, G., Parenti, M.D., et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg. Med. Chem. 25(20), 5849-5858 (2017).

    2. Zuo, Y., Huang, L., Enkhjargal, B., et al. Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats. J. Neuroinflammation 16(1):47, (2019).