A fungal metabolite with anticancer and anthelmintic activities
Related Products
Isomer(s)
29945Colletodiol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Clonostachydiol

Item No. 29066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E,5R,6S,9E,11S,14S)-5,11-dihydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,8-dione
CAS Number
2205018-06-8
Molecular Formula
C14H20O6
Formula Weight
284.3
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C(/C=C/[C@@H](O)[C@H](C)O1)O[C@@H](C)CC[C@H](O)/C=C/C1=O
InChi Code
InChI=1S/C14H20O6/c1-9-3-4-11(15)5-7-14(18)20-10(2)12(16)6-8-13(17)19-9/h5-12,15-16H,3-4H2,1-2H3/b7-5+,8-6+/t9-,10-,11-,12+/m0/s1
InChi Key
SSVNIYICRYPPEB-AATSMRKUSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $236

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Clonostachydiol is a fungal metabolite originally isolated from Clonostachys cylindrospora that has anticancer and anthelmintic activities.1,2 It is cytotoxic to P388 (IC50 = 25 µM), as well as L1210, HT-29, and A549 cancer cells (IC50s = 4.5, 4.2, and 5.7 µg/ml, respectively). Clonostachydiol (2.5 mg/kg, s.c.) reduces fecal worm burden by 80 to 90% in lambs infected with the nematode H. contortus.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grabley, S., Hammann, P., Thiericke, R., et al. Secondary metabolites by chemical screening. 21. Clonostachydiol, a novel anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607). J. Antibiot. (Tokyo) 46(2), 343-345 (1993).

    2. Lang, G., Mitova, M.I., Ellis, G., et al. Bioactivity profiling using HPLC/microtiter-plate analysis: Application to a New Zealand marine alga-derived fungus, Gliocladium sp. J. Nat. Prod. 69(4), 621-624 (2006).