A fungal metabolite with immunosuppressive and antiviral activities
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Isomer(s)
29066Clonostachydiol
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Colletodiol

Item No. 29945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E,6R,9E,11R,12R,14R)-11,12-dihydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,8-dione
CAS Number
21142-67-6
Synonyms
  • (+)-Colletodiol
Molecular Formula
C14H20O6
Formula Weight
284.3
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C(/C=C/[C@@H](O)[C@H](O)C[C@@H](C)O1)O[C@H](C)C/C=C/C1=O
InChi Code
InChI=1S/C14H20O6/c1-9-4-3-5-13(17)20-10(2)8-12(16)11(15)6-7-14(18)19-9/h3,5-7,9-12,15-16H,4,8H2,1-2H3/b5-3+,7-6+/t9-,10-,11-,12-/m1/s1
InChi Key
SHQHOHRUGBYJBS-RSNJVVJKSA-N
Origin
Fungus/Chaetomium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $343

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    Product Description

    Colletodiol is a fungal metabolite that has been found in D. grovesii and has immunosuppressant and antiviral activities.1,2 It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 µg/ml, respectively).1 Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fujimoto, H., Nagano, J., Yamaguchi, K., et al. Immunosuppressive components from an ascomycete, Diplogelasinospora grovesi. Chem. Pharm. Bull. 46(3), 423-429 (1998).

    2. Lai, W., Wang, S., and Ye, X. Colletodiol inhibits the replication of influenza A virus WSN/H1N1 by reducing the activity of viral RNA polymerase. Wei Sheng Wu Xue Bao 53(12), 1334-1339 (2013).