A reducing sugar
Related Products
Isomer(s)
301035-deoxy-D-Ribose
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Product Type

Biochemicals

Research Area

Cancer

2-deoxy-D-Ribose

Item No. 29072

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-deoxy-D-erythro-pentose
CAS Number
533-67-5
Synonyms
  • 2-Deoxy-D-arabinose
  • Thyminose
  • (3S,4R)-3,4,5-Trihydroxypentanal
Molecular Formula
C5H10O4
Formula Weight
134.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC[C@@H](O)[C@@H](O)CC=O
InChi Code
InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1
InChi Key
ASJSAQIRZKANQN-CRCLSJGQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 g

    $36

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    25 g

    $128

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    100 g

    $236

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    Cayman Chemical
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    Product Description

    2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine (Item No. 20519) by thymidine phosphorylase.1 It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM.2 2-deoxy-D-Ribose (10 µM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells.3 Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakajima, Y., Gotanda, T., Uchimiya, H., et al. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res. 64(5), 1794-1801 (2004).

    2. Monti, M.G., Ghiaroni, S., Marverti, G., et al. Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells. Int. J. Biochem. Cell Biol. 36(7), 1238-1248 (2004).

    3. Uchimiya, H., Furukawa, T., Okamoto, M., et al. Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose. Cancer Res. 62(10), 2834-2839 (2002).

    4. Yar, M., Shahzadi, L., Mehmood, A., et al. Deoxy-sugar releasing biodegradable hydrogels promote angiogenesis and stimulate wound healing. Mater. Today Commun. 13, 295-305 (2017).