An internal standard for the quantification of docosanoic acid
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Unlabeled Version(s)
9000338Docosanoic Acid
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Docosanoic Acid-d43

Item No. 29075

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
29823-26-5
Synonyms
  • Behenic Acid-d43
  • C22:0-d43
  • DCA-d43
Molecular Formula
C22HD43O2
Formula Weight
383.9
Purity
≥99% deuterated forms (d1-d43)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
[2H]C(C([2H])([2H])C(O)=O)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C22H44O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h2-21H2,1H3,(H,23,24)/i1D3,2D2,3D2,4D2,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2,18D2,19D2,20D2,21D2
InChi Key
UKMSUNONTOPOIO-MSWDUVJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dean, L.L., and Sanders, T.H. Hexacosanoic acid and other very long-chain fatty acids in peanut seed oil. Plant Genet. Resour. 7(3), 252-256 (2009).

    2. Sánchez-Machado, D.I., López-Cervantes, J., Núñez-Gastélum, J.A., et al. Effect of the refining process on Moringa oleifera seed oil quality. Food Chem. 187, 53-57 (2015).

    3. Iijima, H., Kasai, N., Chiku, H., et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids 41(6), 521-527 (2006).

    4. Yonezawa, Y., Hada, T., Uryu, K., et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. Int. J. Mol. Med. 18(4), 583-588 (2006).

    5. Serviddio, G., Bellanti, F., Villani, R., et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 9, 296-305 (2016).