A long-chain saturated fatty acid
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Labeled Version(s)
29075Docosanoic Acid-d43
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Docosanoic Acid

Item No. 9000338

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
112-85-6
Synonyms
  • Behenic Acid
  • C22:0
  • DCA
  • FA 22:0
  • NSC 32364
Molecular Formula
C22H44O2
Formula Weight
340.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
SMILES
CCCCCCCCCCCCCCCCCCCCCC(=O)O
InChi Code
InChI=1S/C22H44O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h2-21H2,1H3,(H,23,24)
InChi Key
UKMSUNONTOPOIO-UHFFFAOYSA-N
Side Chain Carbon Sum
22:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $28

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    1 g

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    5 g

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    Product Description

    Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dean, L.L., and Sanders, T.H. Hexacosanoic acid and other very long-chain fatty acids in peanut seed oil. Plant Genet. Resour. 7(3), 252-256 (2009).

    2. Sánchez-Machado, D.I., López-Cervantes, J., Núñez-Gastélum, J.A., et al. Effect of the refining process on Moringa oleifera seed oil quality. Food Chem. 187, 53-57 (2015).

    3. Iijima, H., Kasai, N., Chiku, H., et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids 41(6), 521-527 (2006).

    4. Yonezawa, Y., Hada, T., Uryu, K., et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. Int. J. Mol. Med. 18(4), 583-588 (2006).

    5. Serviddio, G., Bellanti, F., Villani, R., et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 9, 296-305 (2016).