An internal standard for the quantification of levofloxacin
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Unlabeled Version(s)
20382Levofloxacin (hydrate)
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Levofloxacin-d8 (hydrochloride)

Item No. 29080

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, monohydrochloride
CAS Number
2699607-50-4
Molecular Formula
C18H12D8FN3O4 • HCl
Formula Weight
405.9
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
FC1=C(N2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(OC[C@H](C)N3C=C(C(O)=O)C4=O)=C3C4=C1.Cl
InChi Code
InChI=1S/C18H20FN3O4.ClH/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H/t10-;/m0./s1/i3D2,4D2,5D2,6D2;
InChi Key
CAOOISJXWZMLBN-DAURPZAXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $499

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    Product Description

    Levofloxacin-d8 is intended for use as an internal standard for the quantification of levofloxacin (Item No. 20382) by GC- or LC-MS. Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Item No. 22891).1 It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).2 Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 μg/ml, respectively).3 It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus.4 Formulations containing levofloxacin have been used in the treatment of various bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Norrby, S.R. Levofloxacin. Expert Opin. Pharmacother. 1(1), 109-119 (1999).

    2. Mohammadhosseini, N., Alipanahi, Z., Alipour, E., et al. Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety. Daru. 20(1), (2012).

    3. Takei, M., Fukuda, H., Kishii, R., et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob. Agents Chemother. 45(12), 3544-3547 (2001).

    4. Entenza, J.M., Vouillamoz, J., Glauser, M.P., et al. Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 41(8), 1662-1667 (1997).