An oxidized form of ascorbic acid
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Dehydroascorbic Acid

Item No. 29089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threo-2,3-hexodiulosonic acid, γ-lactone
CAS Number
490-83-5
Synonyms
  • L-Dehydroascorbic Acid
  • DHAA
Molecular Formula
C6H6O6
Formula Weight
174.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
SMILES
O=C1[C@]([C@@H](O)CO)([H])OC(C1=O)=O
InChi Code
InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1
InChi Key
SBJKKFFYIZUCET-JLAZNSOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 mg

    $49

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    250 mg

    $107

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    500 mg

    $190

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    1 g

    $354

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    Product Description

    Dehydroascorbic acid is an oxidized form of ascorbic acid (Item No. 14656).1 It is obtained through the diet or formed via oxidation of ascorbic acid in the gut and can also be reduced back to ascorbic acid in various cell types. Dehydroascorbic acid (0.5 and 1 mM) inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83%, respectively.2 It also increases glutathione peroxidase (GPX) and glutathione reductase activity and inhibits production of reactive oxygen species (ROS) in hydrogen peroxide-treated astrocytes when used at a concentration of 1 mM. Dehydroascorbic acid (40 and 250 mg/kg) increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered prior to ischemia.3 It also reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at doses of 250 and 500 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilson, J.X. The physiological role of dehydroascorbic acid. FEBS Lett. 527(1-3), 5-9 (2002).

    2. Kim, E.J., Park, Y.G., Baik, E.J., et al. Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes. J. Neurosci. Res. 79(5), 670-679 (2005).

    3. Huang, J., Agus, D.B., Winfree, C.J., et al. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc. Natl. Acad. Sci. USA 98(20), 11720-11724 (2001).