An internal standard for the quantification of caspofungin
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Unlabeled Version(s)
15923Caspofungin (acetate)
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Caspofungin-d4 (acetate)

Item No. 29096

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4R,5S)-5-[(2-aminoethyl-1,1,2,2-d4)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0, diacetate
Molecular Formula
C52H84D4N10O15 • 2C2H4O2
Formula Weight
1217.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly solubleWater: slightly, heated
SMILES
O=C([C@](NC1=O)([H])[C@@H]([C@@H](O)C2=CC=C(C=C2)O)O)N[C@]([H])(C(N3[C@@]([H])([C@H](CC3)O)C(N[C@@H]([C@@H](C[C@@H](C(N[C@@](C(N4[C@]1(C[C@H](C4)O)[H])=O)([H])[C@@H](C)O)=O)NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)O)NC([2H])([2H])C([2H])([2H])N)=O)=O)[C@@H](CCN)O.CC(O)=O.CC(O)=O
InChi Code
InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-;;/m0../s1/i21D2,22D2;;
InChi Key
OGUJBRYAAJYXQP-WRMURXPLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $446

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    Product Description

    Caspofungin-d4 (acetate) is intended for use as an internal standard for the quantification of caspofungin (Item No. 15923) by GC- or LC-MS. Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall.1 It is effective against disseminated or invasive aspergillosis and candidiasis.2,3 Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 µg/ml.4 It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.1,3,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Letscher-Bru, V., and Herbrecht, R. Caspofungin: The first representative of a new antifungal class. J. Antimicrob. Chemother. 51(3), 513-521 (2003).

    2. Abruzzo, G.K., Flattery, A.M., Gill, C.J., et al. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41(11), 2333-2338 (1997).

    3. Deresinski, S.C., and Stevens, D.A. Caspofungin. Clin. Infect. Dis. 36(11), 1445-1457 (2003).

    4. Pfaller, M.A., Boyken, L., Hollis, R.J., et al. In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: A head-to-head comparison using the CLSI M38-A2 broth microdilution method. J. Clin. Microbiol. 47(10), 3323-3325 (2009).

    5. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).