An echinocandin-type antifungal
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Labeled Version(s)
29096Caspofungin-d4 (acetate)
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Caspofungin (acetate)

Item No. 15923

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-lornithine]-pneumocandin B0 acetate (1:2)
CAS Number
179463-17-3
Synonyms
  • L-743,872
  • MK 0991
Molecular Formula
C52H88N10O15 • 2C2H4O2
Formula Weight
1213.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
O=C([C@](NC1=O)([H])[C@@H]([C@@H](O)C2=CC=C(C=C2)O)O)N[C@]([H])(C(N3[C@@]([H])([C@H](CC3)O)C(N[C@@H]([C@@H](C[C@@H](C(N[C@@](C(N4[C@]1(C[C@H](C4)O)[H])=O)([H])[C@@H](C)O)=O)NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)O)NCCN)=O)=O)[C@@H](CCN)O.CC(O)=O.CC(O)=O
InChi Code
InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)
InChi Key
OGUJBRYAAJYXQP-IJFZAWIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Caspofungin is an echinocandin antifungal originally isolated from G. lozoyensis and a derivative of pneumocandin B0 (Item No. 21527).1 It is active against 3,959 Candida clinical isolates (MIC90 = 1 µg/ml), including isolates resistant to fluconazole (Item No. 11594) or itraconazole (Item No. 13288), as well as 38 Aspergillus clinical isolates, including A. flavus, A. niger, A. terreus, and A. fumigatus (MICs = <0.25-64 µg/ml).2,3 Caspofungin inhibits the activity of 1,3-β-D-glucan synthase (IC50 = 0.6 nM in C. albicans membrane preparations).4 It increases survival in mouse models of disseminated candidiasis or aspergillosis.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Letscher-Bru, V., and Herbrecht, R. Caspofungin: The first representative of a new antifungal class. J. Antimicrob. Chemother. 51(3), 513-521 (2003).

    2. Pfaller, M.A., Diekema, D.J., Messer, S.A., et al. In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolate. Antimicrob. Agents Chemother. 47(3), 1068-1071 (2003).

    3. Perea, S., Gonzalez, G., Fothergill, A.W., et al. In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus spp. Antimicrob. Agents Chemother. 46(9), 3039-3041 (2002).

    4. Deresinski, S.C., and Stevens, D.A. Caspofungin. Clin. Infect. Dis. 36(11), 1445-1457 (2003).

    5. Abruzzo, G.K., Flattery, A.M., Gill, C.J., et al. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41(11), 2333-2338 (1997).